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Aside from normal overdoses caused by excessive drug consumption, all hard drugs also have a small, unavoidable chance of causing a major overdose when consumed. This overdose will be of random severity between 0.85 and 0.99 (this is regardless of body size/health scale), and is unaffected by previous overdose severity, meaning that even the first dose could potentially result in a major overdose. The chance of causing a random overdose is 1.5% for [[Flake]], 1.0% for [[Yayo]], and 0.5% for [[Wake-up]] and [[Go-juice]].
 
Aside from normal overdoses caused by excessive drug consumption, all hard drugs also have a small, unavoidable chance of causing a major overdose when consumed. This overdose will be of random severity between 0.85 and 0.99 (this is regardless of body size/health scale), and is unaffected by previous overdose severity, meaning that even the first dose could potentially result in a major overdose. The chance of causing a random overdose is 1.5% for [[Flake]], 1.0% for [[Yayo]], and 0.5% for [[Wake-up]] and [[Go-juice]].
  
The exact likelihood of a single random overdose resulting in chemical damage or death is currently unknown, however in a {{hover title|In Version 1.3.3159|test with a sample of 5,000 random overdoses}}, 5.90% resulted in chemical damage and 5.44% resulted in death, with a total of 11.12% resulting in either chemical damage, death, or both. The chance of a single dose causing permanent damage or death is therefore likely around 0.17% for Flake, 0.11% for Yayo, and 0.06% for Wake-up and Go-juice.
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The exact likelihood of a single random overdose resulting in chemical damage or death is currently unknown, however in a test with a sample of 5,000 random overdoses, 5.90% resulted in chemical damage and 5.44% resulted in death, with a total of 11.12% resulting in either chemical damage, death, or both. The chance of a single dose causing permanent damage or death is therefore likely around 0.17% for Flake, 0.11% for Yayo, and 0.06% for Wake-up and Go-juice.
  
 
Having a drug dependency [[gene]]{{BiotechIcon}} completely removes the random drug overdose chance. However, it is still possible to have a cumulative overdose by taking too much of a drug. Conversely, possessing any drug impervious gene against a hard drug prevents overdoses, both random and cumulative, from all types of drugs.{{Check Tag|Specific or all drugs?|Does an impervious gene actually prevent all random overdoses or just those from the specified drug?}}  
 
Having a drug dependency [[gene]]{{BiotechIcon}} completely removes the random drug overdose chance. However, it is still possible to have a cumulative overdose by taking too much of a drug. Conversely, possessing any drug impervious gene against a hard drug prevents overdoses, both random and cumulative, from all types of drugs.{{Check Tag|Specific or all drugs?|Does an impervious gene actually prevent all random overdoses or just those from the specified drug?}}  

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